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If you’re reading these lines, you’ve probably heard a thing or two about Ayahuasca, this enigmatic and increasingly popular medicine. Perhaps you have friends who have tried it, or perhaps you’ve already tried it yourself and are hoping to dive deeper. With the rapid surge in popularization, new opportunities pop up every day, from basements in Brooklyn to backyards in London, Cape Town or Bali. Itinerant practitioners bring this medicine to every pocket of the world, and new retreat centers open up like mushrooms after the rain. The abundance of choice can be overwhelming, and knowing where to go or who to trust can feel disorienting. In this article, we will attempt to clear up some of the confusion, and provide you with a detailed and well-researched document covering all that you need to know about ayahuasca. We will cover its history, expansion and popularization, its origins in amazonian cultures, adaptations and modern permutation, modern research, spirituality and much more. If you’re feeling the calling to experience what this medicine has to offer, please continue! You’re in the right place. 

Understanding Ayahuasca: From the origin and cultural significance to the ingredients and effects on the brain 

Ayahuasca, a powerful psychoactive brew, has a long and storied history deeply rooted in indigenous Amazonian cultures. The roots of Ayahuasca stretch deep into pre-modern history, although we do not know for certain how far back. Whether it's a matter of centuries, or perhaps millennia, it is certain that people in the Napo River basin were drinking ayahuasca by the time the first European conquistadores made their way down from the Andes Mountains and into the lowlands. These ancient indigenous tribes, riverine communities scattered along the main waterways, cultivated an intimate relationship with their natural surroundings, developing a profound understanding of the botanical world, meticulously identifying and experimenting with countless plant species. 

Among the multitude of botanical wonders that they encountered, the union of Banisteriopsis caapi, a woody vine known for its MAO-inhibiting properties, and the leaves of Psychotria viridis, which contained the psychoactive compound dimethyltryptamine (DMT), proved to be particularly significant. Don’t worry, we will break this apart in a moment. 

Ayahuasca, many people are surprised to find out, is not one singular plant.  This can be confusing, as the word “ayahuasca” often refers both to the prepared brew itself, and also to the Banisteropsis caapi vine itself, a plant that contains tropane alkaloids such as harmine, harmaline, and tetrahydroharmine. While these alkaloids do have an effect on human consciousness, the vine taken on its own does not provide the sort of experiences people seek from the ayahuasca brew. In order to achieve that, we need to add the leaves of a second plant: in most places, the leaves belong to Psychotria viridis, more commonly known as Chacruna, although Diplopterys cabrerana, known as chagropanga, is also fairly common in parts of Ecuador and Colombia.1,2

The chacruna and chagropanga plants, as noted above, contain high concentrations of dimethytriptamine, or DMT. But here’s the thing: Chacruna leaves on their own are completely inactive! You can eat leaves all day and night, and you will feel nothing — perhaps a tummy ache. The magic happens only when these two wondrous plants meet; a true wonder of ethnobotanic sophistication. In order to understand how the magic happens, it is worth to dive a little bit deeper into the unique chemistry of this brew, and how it interacts with our bodies. 

Let's imagine Ayahuasca as a special key and your brain as a locked door. This is a simplistic metaphor, of course, but it will help illustrate this process. Normally, the human body is patrolled by guards (enzymes, mostly found in the gut) whose job is to prevent certain molecules, including tryptamines like DMT, from crossing into our brain. Let’s say that these guards are preventing the key from unlocking the door. We can eat bags of Chacruna leaves, remember? No matter how much DMT arrives to our digestive system, these enzymes (called monoamine oxidase, or MAO), will keep breaking it apart, and we won’t feel any effects. 

For the key to unlock the door, we need to find a way to get those guards to sleep. A magic potion, if you’d like. This magic potion is what we call a monoamine oxidase inhibitor (MAOI). Luckily, this potion can be found quite readily in the form of tropane alkaloids like harmine and harmaline, the main active components in the ayahuasca vine. Now, with the enzymes neutralized, the DMT can slip past the sleeping guards and unlock the door to your mind.

This ingenious, visionary concoction soon found its place in the spiritual and cultural framework of Amazonian life. As culture spread, so did Ayahuasca, becoming rooted in different tribes and known by various local names and in different languages. The best known one, besides ayahuasca, is yagé, a name used mostly in the northern range of the basin, in Ecuador and Colombia. The Shipibo people call it Oni, meaning “knowledge” or “wisdom”, while the Santo Daime traditions of Brazil refer to ayahuasca as Daime. 

Regardless of the local name given to the brew, throughout its range it has held diverse roles within these cultures. Shamans, or the people who occupy social roles that, for the sake of simplification, are akin to “shamans”, like the spiritual leaders and healers of these communities, recognized Ayahuasca as a sacred sacrament capable of facilitating profound connections with the spirit world. Its consumption became an integral part of tribal rituals, healing ceremonies, and initiation rites. It was not merely a means of inducing altered states of consciousness but rather a gateway to deeper insights, a source of healing, and a channel for receiving guidance from ancestral spirits and the natural world.

The knowledge of Ayahuasca's preparation and use was —and still is— meticulously passed down through generations, often through oral traditions and apprenticeships under experienced teachers, and learnt directly from the plants. It is considered a cultural treasure and a bridge between the physical and spiritual realms, representing the essence of the Amazonian worldview. In contemporary times, ayahuasca is even institutionally recognized and protected as part of the national cultural heritage in some South American countries, like Peru, Colombia and Brazil.  

While indigenous populations in the Amazon had kept the knowledge of this sacred medicine safe through centuries of European conquest, colonization and violence, ayahuasca fell into relative obscurity for many centuries. Shamanism was deemed a heresy, and shamanic practices, like the use of ayahuasca and other psychoactive plants and cacti were banned and demonized throughout colonial times. Practitioners were often persecuted, as the church saw the use of entheogenic substances as a threat to their growing religious influence. Ayahuasca was driven deeper and deeper into the underground, disappearing from many lineages and tribes, while becoming an important tool for resistance and survival for others. 

It wasn’t until the 20th century that ethnobotanists, anthropologists, and researchers from various fields “re-discovered” ayahuasca, and embarked on journeys deep into the Amazon rainforest to uncover the botanical, cultural, and psychoactive secrets of this enigmatic brew. Figures like Richard Evans Schultes, an American ethnobotanist, and the McKenna brothers, were among the pioneering figures who re-ignited western interest in psychedelic plant medicines. They were particularly keen to explore the pharmacology and psychopharmacological effects of ayahuasca, paving the way for a broader understanding of Ayahuasca as not merely a psychoactive substance with therapeutic benefits, but a complex relational, social, cultural and spiritual phenomenon.3

The expansion and globalization of Ayahuasca Plant Medicine

Over the last couple of decades, ayahuasca has spread well beyond the Amazon rainforest and become a true cultural phenomenon.  Several factors, including increased travel and communication, growing interest in alternative healing modalities, and the desire for profound spiritual experiences, have contributed to the rapid expansion and globalization of ayahuasca-based practices. 

Ayahuasca retreats and ceremonies have sprung up in countries far removed from its indigenous origins, attracting individuals from diverse backgrounds seeking inner healing, self-discovery, and spiritual awakening. Its contemporary significance lies in its capacity to bridge cultures, foster intercultural dialogue, and provide a unique avenue for personal growth and introspection. Moreover, Ayahuasca has garnered scientific attention for its potential therapeutic applications, particularly in the treatment of mental health disorders, offering a promising alternative to conventional pharmaceutical approaches. As Ayahuasca continues to weave its threads into the global tapestry, it serves as an individual and collective catalyst for well-being, spiritual connection, and a deeper understanding of consciousness.

According to research by ICEERS, the International Center for Entheogenic Education, Research and Service, it is estimated that approximately four million individuals worldwide have taken Ayahuasca at least once. Around 800,000 people experience Ayahuasca in one year, with the total number of Ayahuasca ceremonies conducted reaching approximately five and a half million. The report also claims that at least 232 Ayahuasca retreat centers exist, operating in Amazonian countries and Costa Rica. A significant portion of these centers, nearly three-quarters, can be found in Peru.4

However, it's crucial to acknowledge that the majority of Ayahuasca experiences unfold beyond the borders of Peru and the Amazon region. In fact, a significant portion of Ayahuasca ceremonies occurs in the Global North. According to the same report by ICEERS, the total global yearly count of approximately five and a half million Ayahuasca experiences, and considering that 210,000 of these occur in Amazonian retreat centers, we are left with an astounding 5,300,000 Ayahuasca experiences taking place in various locations worldwide.

So what should we do? Where should we go? Which questions should we ask, and who should we trust? How do we know that we will be cared for, that we will be safe and comfortable?

In the next section, we will answer all these questions and more so you can make the best possible choice for your unique needs. 

Choosing the Ayahuasca retreat that is right for you 

The first thing that we need to do is to get clarity about our own desires and motivations. We have decided that we want to try ayahuasca, but why? There are several valid reasons why a person might be inclined to explore this medicine, and being clear about it could help us find the setting that best caters to our needs. 

For example, many people are drawn to ayahuasca for its potential to help us advance on our healing journey. Ayahuasca can help us address trauma, relational difficulties, or to better understand the deeper roots of experiences like anxiety, depression, or other mental and emotional health issues. If we have experienced trauma in our lives, and we have a sense that some of it still needs to be unpacked, it might be a good idea to be well informed about the skills and experience of the person or team we may be working with. If we have an explicit intention to address past traumas, making sure that there are trauma-informed practitioners might be an important thing. 

For other people, the healing they seek might be more relational. For example, we might be going through a period of grief after the end of a meaningful relationship, or the passing of a person close to us. Ayahuasca can be a helpful ally as we endeavor to heal our hearts and create spaciousness around that loss. 

Other motivations can include recovery from addiction, in which case we need to make sure that we pick a facility that is equipped and staffed accordingly, as not every retreat center has the resources or the staff needed to support a recovery process. For example, we might want to make sure that the place that we choose has trained medical doctors and nurses on site. We might want to make sure that they have sufficient experience and tools to ensure our safety and support our success.

People might also be interested in ayahuasca for personal transformation, spiritual growth, to enhance a metaphysical practice or to explore their own consciousness and deepen their knowledge of themselves. For some people, curiosity might be enough of a valid and simple motivation to embark on this journey! And still, it is important to choose an environment that feels safe, has a good reputation and is operating within the boundaries of the local system of law. 

Factors to consider: Reputation, safety, set and setting 

Regardless of the motivation, when it comes to ayahuasca it is important to find a reputable, trustworthy provider or retreat center. While some people might have had previous experiences with psychedelic substances and fungi, alone or with friends, making the most of the ayahuasca experience requires the utmost attention to detail when it comes to reputation, set, setting and safety. 

Firstly, It is important to undergo these experiences under the care and supervision of experienced shamans and practitioners, even if you’re an experienced meditator, psychonaut or energy worker. The ayahuasca space is unlike any other, and navigating it on our own can be challenging, regardless of experience or dosage. Being able to trust the person who is holding space is crucial, as we might find ourselves in vulnerable situations where we will need to reach out for help. 

Simple things like going to the bathroom (don’t worry, you will make it on time!), navigating the physical space while we feel disoriented, or getting through a tight psychological or emotional spot are not uncommon experiences during an ayahuasca ceremony. The staff that is attending the ceremony must be experienced and trustworthy, so we can let go and surrender to the fullness of what the medicine is trying to show or teach us. Knowing that kind, wise people have our back makes a huge difference, putting our minds at ease and allowing us to go as deep as we can in our own individual journey.

Although ayahuasca can provide life-changing transformational experiences, deep emotional, relational and psychological healing, and many other benefits, it is not without risks. Ayahuasca can have potent physical and psychological effects. Without proper preparation, dosage control, and medical supervision, there are risks of adverse reactions, including certain physical and mental health complications. Like most activities that entail a degree of risk, making sure that we are working with experienced and skilled practitioners in a thoughtful and regulated environment will help us minimize risk and maximize potential benefits. 

As we have seen above, ayahuasca practices are deeply rooted in rich, living indigenous cultures. Engaging with spiritual traditions must be done with deep respect and care for the people who have kept these traditions alive, and who are still guardians of this sacred knowledge. In a fast, consumerism-driven world, it is easy to lose sight of the need for respecting interdependence and reciprocity; if we benefit from knowledge and wisdom that is integral to a lineage or a cultural group, it is important that they are receiving something of equal value in return.

Be sure to do your homework. On one side of the spectrum, you have retreats in the middle of the jungle, hours away from medical care and with little to no preparation or integration support. On the other, you have Rythmia: the only medically licensed plant medicine center in the world offering a 7-day time-tested, proprietary program. The all-inclusive Rythmia experience includes four meticulously designed Ayahuasca ceremonies, extensive metaphysical classes to help you prepare for and understand your experience, supporting modalities such as breathwork and yoga, a comprehensive 90-day post-visit integration program, and much more, all within a breathtaking gated community in Guanacaste, Costa Rica that provides premium accommodations and extensive amenities. 

Post-Ayahuasca Ceremony: The Importance of Integration

There’s one crucial component that can make or break an ayahuasca experience: the integration. Integration is not just a trendy buzzword; it is the opportunity to allow ourselves to fully embody the insights, revelations, wisdom and healing that we receive so we can make actual positive long-term changes in our lives. One thing is how we feel the day after the ceremony, and another very different thing is how we feel a few days later when the afterglow of the experience has started to fade and we are once again sitting in traffic amidst the hustle and bustle of our daily stressors and pressures. 

The insights we receive during ceremony can feel inherently life-changing — and they can be, but just having those experiences is not enough. Integration means that we need to make sense of those experiences, reflect on what they mean for our lives, and chart a map to help us get from A to B. Sadly, we still don’t have silver bullets and magic pills, panaceas and cure-alls. Not even ayahuasca. The medicine can show us the path, but we still need to walk it. It can give us insight into which areas need more care and attention, and it is up to each of us to do the work and transform our own lives. 

Integration is a multifaceted endeavor that can be supported by skilled professionals along the way. From coaches to therapists or personal trainers, getting help from experienced individuals can have a big impact on our journey. When we choose to drink ayahuasca, it is important to know what kind of support will be available to us, both in the short and the long terms. It will be crucial to be around skilled and experienced facilitators who can help us process and make sense of our experiences in the hours and days following the ceremony. Group shares, integrative activities and opportunities to process mental and emotional content should be built into the program.

Likewise, it is important to ask about opportunities for longer-term integration programs. Does the retreat center offer continuing education programs? A container for the group to continue bonding and relating? Do they work with coaches or therapists who can provide longer-term one-on-one support? Do they put enough emphasis on helping you chart your own integration blueprint? Remember: the ayahuasca retreat itself can often be challenging in itself — but the bigger challenge is to seize the opportunity to really change our lives for the better, and have a positive impact on ourselves, our families and our communities.  

So, as a quick recap for this section: there are a few crucial things that we want to make sure of before we book a retreat. We want to know that the people we will be working with are skilled, safe and reputable. We want to know which traditions they learnt from, and what they are actively doing to give back and honor those traditions and communities. We want to make sure that the environment where we will be surrendering to a transformational experience is equipped to hold that space, materially, spiritually, and legally, with top-notch facilities and equipment, the best possible human capital, and good standing with the local governance system. Lastly, we want to ensure that participants will have enough resources to make sense of their experiences, leaving them inspired and energized, with the clarity to move forward in their integration journey. 

Once we have narrowed down our options, and we have a clearer idea of which places are best suited for our needs, it can be valuable to read reviews and listen to testimonials left by previous guests of the program. Testimonials provide valuable information, as they are often provided by people who genuinely benefited from their retreat and they’re eager to let others know about their experiences. Unlike commercial ads, the people doing testimonials are not paid. Their messaging is sincere and speaks to the heart of their own healing and transformation. 

How do I prepare for a retreat? From the “dieta” and medications to what to pack and emotional preparation

Before you leave for the experience of a lifetime, there are a few things that you need to prepare, both spiritually and materially. On a spiritual level, we need to start working on setting intentions, in a more precise manner. On a material level, we need to know what to pack; an ayahuasca retreat is a unique environment that requires some unconventional items. Furthermore, we need to prepare our bodies and minds, a task that requires certain adjustments to our diet and habits. 

One of the crucial aspects of the preparation is following a “dieta”: a set of dietary and behavioral guidelines often followed in preparation for and after working with plant medicine. This aims to cleanse the body and mind, enhance the effects of the medicine, and help individuals connect more deeply with the spirit of Ayahuasca. Dietas typically advise avoiding processed foods, refined sugars, and artificial additives. Additionally, red meat and pork are often excluded, with some practitioners even opting for a vegetarian or vegan diet to enhance spiritual receptivity. Fermented foods, spicy dishes, and items rich in tyramine, like aged cheeses and cured meats, are discouraged due to potential interactions with the brew. Alcohol and caffeine should be abstained from, as they can interfere with the Ayahuasca journey. Excessive salt and oil consumption should also be minimized to maintain physical and energetic balance. 

On the other hand, dietas often emphasize an abundance of fresh fruits and vegetables, whole grains like quinoa and brown rice, as well as plant-based proteins such as lentils and tofu. Hydration through water and herbal teas is essential to support the body's physical and energetic balance. 

Dietas are not only about what we eat, but also about what we do. In terms of behavior, it is recommended to abstain from sexual activities before the ceremony to conserve vital energy and encourage inward focus. To cultivate an environment conducive to inner exploration, minimizing exposure to excessive noise, media, and stressful situations is beneficial. Spending time in nature and engaging in mindfulness practices like meditation, yoga, or journaling can help attune the mind and spirit.

Many retreat centers have specific requests related to drugs and supplements, legal and illegal. At some point during the intake/onboarding process, you might be required to disclose all medications, drugs, supplements, and psychedelics taken within the past year. In general, one should not be taking any other supplements or medications, including herbal medicines, when taking plant medicine, both for your safety and to not interfere with the efficacy of the plants or their energies. It is extremely important to be fully transparent and to follow the specific guidelines even if you’ve attended previous ceremonies or retreat centers where they had different requirements. It is not only about pharmacological interactions but about the sort of energies that each shaman or each lineage is taught to work with. If you have a concern about a specific treatment, it is important that you communicate swiftly and directly. 

Beyond following the dieta, it will also be important to prepare ourselves mentally and emotionally. The preparation is simply to begin —or continue— cultivating an open and receptive mindset, acknowledging personal intentions and concerns, and being ready to confront and process emotions and insights that may arise during the ceremony. If you have a spiritual or contemplative practice, like meditation, tai chi, or yoga— great. Continue to deepen your practice. If not— that’s also great. This is a great opportunity to become curious and explore tools and practices that can help you cultivate self-reflection and contemplation. 

It will also be important to continue setting clear intentions, and maintaining a sense of trust in the whole process: this will help you navigate the journey with greater clarity and purpose. It's important to approach the experience with humility and an attitude of surrender, recognizing that Ayahuasca may reveal deep-seated emotions and offer profound healing. This might not always be pleasant or comfortable and that’s perfectly okay! Healing is not always pretty, and going deep can be messy. Adequate mental and emotional preparation can lead to a more meaningful and transformative Ayahuasca journey and set the tone for a solid integration process. 

Packing for an ayahuasca retreat is a little bit different than packing for a regular “vacation”, and it will depend a lot on the retreat center you choose. If you’re traveling to a tropical country, like Costa Rica or Peru, you might want to check whether you’re traveling during the rainy or the dry season. Remember, temperatures in the tropics are always hot and humid, but not always drenched in rain. Furthermore, since you’re going to be doing some deep personal spiritual growth, you want to avoid bringing with you too many distractions. A book is fine, but maybe consider leaving laptops and iPads behind. The more you’re able to focus inward, the better. 

Taking into account you’ll likely be in the tropics, packing essentials include light and comfortable clothing, warm layers for cooler nights, rain gear if necessary, comfortable footwear, a flashlight or headlamp, personal toiletries, insect repellent (natural can be fine, but bring some stronger one just in case!), a reusable water bottle, a notebook and pen for journaling, an eye mask and earplugs for ceremony comfort, any sacred or personal items, valid travel documents, prescribed medications (remember to check the dieta restrictions with your retreat center first!), a basic first-aid kit, cash in the local currency, cellphone charger and a travel adapter if needed.

The Ayahuasca Experience

During an Ayahuasca ceremony, participants can anticipate a deeply introspective and often profound journey. It's impossible to give a comprehensive description of what the experience is like, as experiences are always different and vary greatly from one person to another and even from one ceremony to the next. In the ayahuasca world, we often say that “ayahuasca never gives you what you want, but it always gives you what you need”. This is probably the best way to approach an experience that is in essence, indescribable: with openness, surrender, and trust that whatever happens is that is meant to happen. 

In more practical terms, the ceremony typically takes place in a designated space, often referred to as a “maloka”, a name of amazonian origins meaning a communal house. The space may be adorned with spiritual symbols and the session is conducted by an experienced and skilled shaman or facilitator. The ceremony typically begins in the evening and lasts several hours, with some ceremonial designs lasting all night Participants drink the Ayahuasca brew, provided by the facilitator, and the effects usually begin within 30-60 minutes, although these times can vary depending on several factors like each persons metabolism, the strength of the brew, or, some would say, the whim of the plant spirits. Experiences may include vivid visions, emotional releases, physical tremors and temperature changes, revisiting biographical memories and encounters with spiritual or symbolic entities. 

Music, often provided by the shaman or facilitators, plays a crucial role in guiding the journey. Ceremonies emphasize introspection, healing, and personal growth, with participants encouraged to set intentions for their experience. Intention can be important, although it’s important not to get too attached, and let the experience flow in its own terms. Like our own breath, the intention can be useful as an anchor to keep coming back to if our mind keeps wandering off. 

Vomiting or "purging" is a common —and essential— part of the process, believed to release physical and emotional toxins. Almost every ceremony will include a bucket for each participant to puke into. Hold on tight to your puke bucket! Cleansing your body and your mind are important parts of the process. In many amazonian languages, the local names for ayahuasca literally translate to “the purge”, illustrating how important this experience is for these traditions. 

Purging can happen in different ways: vomiting being the most common one although sometimes the medicine will also cleanse our bodies from the lower end. It is common for people to be apprehensive about this part, and often fear that they won’t be able to make it to the bathroom in time, and will be forced to deal with the shame of pooping their pants. Facilitators are aware of this, and will often reassure participants that there’s nothing to worry about, as almost always people are in control and aware enough to make it to the toilet, and even in the rare occasion when accidents happen, facilitators will help you wash, change clothes, deliver a fresh mattress and make sure that you will be laughing about the whole thing soon enough. 

The ceremony often concludes with a grounding period, followed by a group sharing. The group share is an opportunity to connect with other participants and be a witness to their experiences, while sharing yours. A group share will typically happen in the following morning, although some people like to do it right after the ceremony has ended. Furthermore, facilitators will share integration practices to help participants make sense of their experiences and apply insights to their lives. Remember: the real “work” often begins after the ceremony ends, and it is time to make the changes and adjustments necessary so we can continue growing. 

It is important to understand that ayahuasca experiences can present some potential challenges. Ayahuasca can help uncover deep-seated emotions, and elicit intense visions or physical and emotional discomfort. These experiences can also rattle our maps of the world, and catalyze deep existential processes, as we create new, wider models of what the world is, what entities or beings exist in it and what is our place in it. To navigate these challenges, it's crucial to approach the experience with humility, an open heart, and a willingness to surrender to the process. Cognitive and epistemic flexibility, or the capacity to absorb or hold new information about the world even when it conflicts with pre-existing models, can make things a bit smoother as we let go of old belief systems. 

Following the post-dieta recommendations and being diligent with the post-ceremony integration practices, such as journaling, meditation, or therapy, can help make sense of the experience. Lastly, comparing our experiences with each other is not always useful: each experience is unique, and tailored to what each person needs. Comparisons will most likely lead to frustration, as opposed to appreciation and gratitude for our own personal journeys. 

Post-Ayahuasca Ceremony Integration

In previous sections, we’ve already touched on the subject of “integration”. Yet this part is important enough that it is worth repeating and expanding in its own section. I will write this again: Post-Ayahuasca integration is a crucial phase in maximizing the benefits of your Ayahuasca experience. We can think of integration as the bridge that connects the insights gained during the ceremony and their practical application in daily life. Remember: there are no magic bullets. Insights do not become embodied wisdom and lifestyle changes on their own. They need grounding into the realities of our day to day, translated into new habits and routines. 

To navigate this process effectively, it's essential to set aside dedicated time for reflection and processing, whether through journaling, meditation, or therapy. If you already have integrative practices that you like to do, go deeper! Creating a support network of fellow participants is often facilitated by the retreat, via Facebook or WhatsApp groups and periodic check-ins. Some people feel that a therapist can offer valuable perspectives and assistance in making sense of their journey, particularly when faced with challenging content that takes time to integrate. 

Remember, healing is not linear, and it doesn’t happen in a day. Healing and growth are more like a spiral, or an ebb and flow; changing deeply rooted habits and adopting new ones takes time, and we will often feel like we aren’t making enough progress or we are regressing. It is okay. This is a part of the journey, and the only measure of success is to keep coming back to our breath, our bodies, the insights we received from the medicine and to continue with the integration process. 

Ayahuasca Healing, Transformation and Scientific Research 

Ayahuasca has shown promising therapeutic potential for mental health and addiction issues.5 Its unique psychoactive properties, which induce profound introspection and emotional release, can facilitate the processing of trauma, anxiety, depression, grief and other psychological challenges. It’s important to note, that the benefits of ayahuasca cannot be reduced solely to its unique chemistry; there are many factors beyond the brew that also play a part in the process. The group interactions, the social setting, the sense of community that forms around the experiences, and the integrative practices that might be on offer like yoga, breathwork, meditation or dance. Relaxation time and good food are crucial for integration. Ayahuasca healing really is holistic: it takes a jungle, or rather, a whole set of professionals and open-hearted participants supporting each other through their journeys.

While it's difficult to take the jungle to the lab, and most studies have been done in a more naturalistic setting, Ayahuasca-assisted therapy is being explored as a complementary approach to traditional psychotherapy, with good preliminary results.  Additionally, Ayahuasca has demonstrated the ability to address addiction by providing individuals with insights into the root causes of their addictive behaviors and fostering a shift in mindset. This is an important thing to highlight: ayahuasca doesn’t cure the addiction, but it allows the person to understand better what the addiction is a result of, and what is the deeper source of the pain so it can be addressed. Remember, not all retreat centers are well-equipped to deal with addiction recovery, so it's best to inquire about your specific needs. 

Healing and transformation do not refer only to lifestyle changes, the amelioration of physical or mental symptoms or addiction. Confronting and processing unresolved emotional wounds, trauma, and negative thought patterns is great. However, Ayahuasca experiences may also offer insights into broader existential, philosophical, religious or spiritual questions. Ayahuasca can help us with insights about the things that are truly meaningful to us, our life purpose, or deliver ineffable, mystical experiences of oneness and interconnectedness with the universe. 

These experiences are harder to talk about as they often transcend the capacity of language to describe subjectivity. These experiences tend to be very sacred and very personal, and they are often described by participants as some of the most meaningful, and even miraculous, experiences of their lives. Remember, it’s important to let go of expectations and embrace the experiences that we get. Clinging to an expectation that we should experience one thing instead of the other, or comparing our experiences with somebody else’s will inevitably result in frustration. People often say “everything happens for a reason”, and with ayahuasca, that seems to be true. 

So how much should I expect to pay for a retreat?

Like anything else, this depends on several things! Attending an Ayahuasca retreat typically involves several costs. Some retreats may offer various package options, so the overall cost can range from hundreds to thousands of dollars. These costs may include the retreat program fee, which can vary widely depending on the location, duration, and amenities provided. Additionally, participants may need to budget for travel expenses to reach the retreat center. This can quickly make the whole adventure more expensive, depending on where you are planning to travel to. The more remote, the more time and resources you’re likely to spend to reach your destination. Other factors that can increase the price include different options for accommodations, meals, and any additional activities or ceremonies beyond the Ayahuasca sessions. 

If you’ve read your way all the way down here, by now you probably understand the importance of finding the best possible program, led by skilled, experienced and ethical shamans and facilitators, all supported by a safe, comfortable, and luxurious environment. You want to make sure that there are enough communal areas where you can relax and bond with your peers; dining areas, saunas, a nice pool. You also want to make sure that you have enough privacy to retreat into the comfort of your own room, a good mattress to replenish your energies and —if you are in the tropics— air conditioning doesn’t hurt. 

It is important to research and choose a retreat that aligns with your budget and preferences while ensuring the center is reputable and prioritizes safety. And really, how many times are you going to book the retreat of a lifetime? Do your homework diligently and book the one best suited for what you need. 

A quick recap of all the things we have covered 

In this article, we have learned that it's essential to consider several key factors before we embark on a safe and transformative journey with Ayahuasca. I would like to reiterate the main insights and encourage you to continue to discover ayahuasca on your own. Firstly, thorough research is paramount. Educate yourself about Ayahuasca, its effects, and its potential benefits and risks. Consider your personal reasons for seeking Ayahuasca, whether it's for healing, self-discovery, or spiritual growth. Reflect on your intentions and what you hope to achieve through this experience. 

Prepare yourself mentally and emotionally, set clear intentions for your journey, and create a supportive environment. Comply with the recommended dietary guidelines leading up to the ceremony to prepare your body, mind and spirit. Financial planning is also essential. Be aware of the costs involved in attending a retreat, including program fees, travel expenses, and accommodations. Lastly, trust your intuition when choosing a retreat. Ensure it aligns with your values and goals, and feel confident in your decision. 

Understanding the significance of set and setting is crucial. Ensure you choose a reputable retreat center with experienced facilitators who prioritize safety, ethics, and the well-being of participants. With careful preparation and discernment, you can embark on a safe and meaningful Ayahuasca journey that has the potential to bring profound insights and transformation.

Welcome to Rythmia in beautiful Costa Rica!

Nestled amidst the lush landscapes of Costa Rica's Nicoya Peninsula, renowned as one of the world's Blue Zones where people enjoy happier, healthier, and longer lives, Rythmia offers an extraordinary and thoughtfully designed transformational experience. With its world-class facilities, luxurious accommodations, and a range of amenities including a spa with a cold plunge and sauna, as well as a saltwater pool, seasoned shamanic guides, skilled facilitators, and exceptional thought leaders, an unwavering commitment to safety and ethical standards, Rythmia warmly extends an invitation for you to embark on a profound journey of self-discovery, inner exploration, and what many have come to regard as miraculous personal growth.

As the world's only medically licensed ayahuasca center, Rythmia has been serving guests since 2016, with over 15,000 individuals having successfully completed our transformational program. Through the Rythmia Way program, guests have the opportunity to engage in ayahuasca ceremonies, complemented by yoga, metaphysics classes, volcanic mud baths, life coaching, hydrocolonic cleanses, exclusive breath-work modalities, massages, and farm-to-table, dieta-friendly organic cuisine. RLife, our comprehensive 90-day post-stay integration program with ongoing access to classes, live group classes, and more, is included with your stay.  

Rythmia is resolutely committed to ensuring the absolute satisfaction and safety of every guest. We take pride in our impressive 2:1 staff-to-guest ratio, which includes a highly skilled plant medicine ceremony team and an on-site medical team comprising doctors, nurses, and Emergency Medical Technicians. 

Rythmia's reputation as an industry leader is backed by more than 2,400 five-star reviews on TripAdvisor. We know we are the best—our conviction is affirmed by the remarkable statistics: 97% of guests who undergo the Rythmia Way program report experiencing a life-changing miracle, and 15% return to Rythmia for continued self-knowledge, and deeper personal evolution.

Our esteemed Board of Directors, featuring distinguished individuals like Martin Luther King III, Kelly Slater, Toni Ko, and Cesar Millan, among others, have been thoughtfully selected because they share a collective vision of empowering others to lead their absolute best lives. Our guest speaker program includes influential thought leaders such as Reverend Michael Bernard Beckwith and Jack Canfield, who also serve as board members, as well as luminaries like Iyanla Vanzant and the brilliant minds of Neurohacker Collective.

Whether you are new to Ayahuasca or on a quest to deepen your spiritual journey, Rythmia provides an inviting and transformative space to explore the profound potential of this ancient plant medicine. Discover the healing power of Ayahuasca at Rythmia and embark on a journey toward greater self-awareness and spiritual awakening.


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2. Riba, J., Valle, M., Urbano, G., Yritia, M., Morte, A., & Barbanoj, M. J. (2003). Human pharmacology of Ayahuasca: Subjective and cardiovascular effects, monoamine metabolite excretion, and pharmacokinetics. Journal of Pharmacology and Experimental Therapeutics, 306(1), 73-83.

3. Schultes, R. E. (1957). The Identity of the Malpighiaceous Narcotic Huilca. Botanical Museum Leaflets, Harvard University, 18(5), 149-172.


5. Hofmann, S. G., Curtiss, J., & McNally, R. J. (2016). A therapeutic alliance explanation for the efficacy of Ayahuasca-assisted addiction treatment. Journal of Psychoactive Drugs, 48(3), 195-213.

Dos Santos, R. G., Osório, F. L., Crippa, J. A., Riba, J., Zuardi, A. W., & Hallak, J. E. (2016). Antidepressive, anxiolytic, and antiaddictive effects of Ayahuasca, Psilocybin and Lysergic Acid Diethylamide (LSD): a systematic review of clinical trials published in the last 25 years. Therapeutic Advances in Psychopharmacology, 6(3), 193-213.

Sanches, R. F., de Lima Osório, F., Dos Santos, R. G., Macedo, L. R. H., Maia-de-Oliveira, J. P., Wichert-Ana, L., ... & Hallak, J. E. C. (2016). Antidepressant effects of a single dose of Ayahuasca in patients with recurrent depression: a SPECT study. Journal of Clinical Psychopharmacology, 36(1), 77-81.

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